“Abuse of cocaine is a serious problem in America,” says Weinstock. “Cocaine is involved in more than a third of emergency-room visits for drug misuse or abuse. And because it shares characteristics with many other addictive substances, our findings could apply to opioid and other addictions.”
The National Institute on Drug Abuse has made a $4M grant to JAX scientists to explore the roles of the microbiome and genetics in substance use disorders.
The National Institute on Drug Abuse (NIDA) has funded a bold new approach to understanding the biology of substance abuse, with a five-year grant totaling $3,967,656 to Jackson Laboratory (JAX) researchers exploring the role of the microbiome and genetics in substance use disorders.
…NS is extremely rare, it is a severe and unmet need…
“I’m thrilled to receive this funding and am honored to be joined by Dr. Julia Oh at JAX for this research,” said Travis Whitfill, MPH, Founder and Chief Scientific Officer, Azitra. “Although NS is extremely rare, it is a severe, unmet need and patients are desperate for new treatment options. We hope to bring forward a novel, microbe-based therapy, AZT-02, to deliver missing proteins as a viable therapeutic strategy. This project demonstrates the versatility and importance of our microbe-based platform to deliver proteins to the skin.”
Photo by Helloquence on Unsplash
- Intermittent Fasting (IF) ameliorates the clinical course and pathology of the MS mouse model (EAE)
- IF increases gut microbial diversity, alters their composition and metabolic pathways
- Gut microbiota transfer from mice on IF led to protection from EAE in recipient mice
- Findings with IER in MS patients partially recapitulates what is observed with IF in EAE
A new paper in the journal Cell Metabolism shows that intermittent fasting (IF) can improve symptoms of multiple sclerosis, and that the effects are likely due to changes in the gut microbiota. George Weinstock and Yanjiao Zhou of The Jackson Laboratory were among the microbiome experts involved in the research.
Can fasting improve MS symptoms? Medical Express
Intermittent fasting may benefit people with MS Medical News Today
“The microbes that live on our skin come into direct contact with myriad things from our environment — toxins, chemicals, other microbes — and they interact with molecules produced by our own cells to help maintain a healthy first line of defense against the outside world.”