Capabilities

The combined resources of our member institutions provide an impressive range of enabling capabilities for microbiome research.

Capability   Providers

Development-oriented projects with human subjects

HIPAA-compliant access to clinical specimens Yale Center for Clinical Investigation (YCCI)

Clinical Trials Unit at CCMC

HIPAA-compliant infrastructure for clinical trial execution

Identify, consent & enroll patients

Manage database records, sample collection and distribution

Yale Center for Clinical Investigation (YCCI)

Clinical Trials Unit at CCMC

Exploration of company/sponsor clinical research questions in the context of ongoing clinical and translational research programs studying the influence of the microbiome on disease processes Yale

UConn Health

CCMC

Pipeline for isolation of fastidious microbes from human gut Yale

JAX

 

Sequencing and Analysis

Microbiome profiling of clinical specimens to validate discoveries, test microbiome impacts of intervention, and in the context of clinical trials JAX

Yale

Genome sequencing to enhance value of strain collections, including NGS and transcriptome profiling JAX

Yale

UConn

Training modules and workshops for customer/sponsor staff to learn microbiome sample processing and analysis UConn

JAX

Informatics and data analysis for ultra-high volume data generated in microbiome analysis; services can be provided as sponsored research, collaboration, and/or training in relevant programming and data analysis skills Yale

UConn

JAX

Microbiome sequencing analysis in a CLIA environment JAX

Yale

Microbiome biomarker assay development for a CLIA environment JAX

Yale

 

Existing Strain Collections

Provision of >2,000 isolated strains from the human microbiome. Mechanistic studies of the role(s) of specific microbes in health/disease and direct probiotic products JAX

Yale

Provision of >10,000 isolated strains from invertebrate and environmental microbiomes for discovery of antimicrobial and other bioactive compounds in function-based screens UConn
Culturing and characterization of anaerobic and other fastidious organisms, built on deep expertise and specialized equipment JAX

Yale

UConn

 

Animal & environmental models for screening and validation testing

Germ-free mouse research studies to dissect the functional interaction between one or more defined microorganisms and host health or disease-related responses Yale
Functional characterization of microbial species, including mass spectrometry-based metabolite profiling Yale
Functional characterization of microbial isolates in vitro; in vivo functional classification in germ-free mouse models JAX

Yale

Development of custom microenvironmental devices for functional microbiome testing UConn
 

Environmental discovery of isolates with secondary metabolite activity

Discovery and analysis of environmental isolates with antimicrobial activity UConn:   Molecular & Cell Biology; Pharmacology; Chemistry
Isolation, extraction and screening of environmental microbiome isolates for secondary metabolite activity UConn
Screening of isolates or compounds identified by companies/sponsors UConn